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16S rRNA sequencing showed that excessive APAP significantly changed the composition and diversity of gut microbiota, including increasing the ratio of Firmicutes / Bacteroidetes and reducing the abundance of Proteobacteria , Roseburia , Lactobacillus , Akkermansia muciniphila and Saccharomyces cerevisiae ( 81)

Proc Natl Acad Sci USA 113(16):44764481 Wu FT et al (2016) Efficacy of cotargeting angiopoietin-2 and the VEGF pathway in the adjuvant postsurgical setting for early breast, colorectal, and renal cancers

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The cluster of fragments found to bind in the leucine pocket across both TRF1 TRFH XChem screens strongly validates the ligandability of this site and the possibility of developing potent inhibitors of the TRF1:TIN2 protein:protein interaction